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The HOPE score is the result of an international collaborative project initiated and led by the Emergency Department of the University Hospital of Lausanne, Switzerland.

The HOPE score provides a prediction of the survival probability in hypothermic cardiac arrest patients undergoing Extra-Corporeal Life Support (ECLS) rewarming. The score ranges from 0% to 100% chance of survival to hospital discharge.

A cutoff of 10% to decide which hypothermic patients in cardiac arrest would benefit or not from ECLS rewarming was evaluated in an external validation study. The negative predictive value of a HOPE score <10% was of 97%, and the AUC under the ROC curve was of 0.825 which suggest excellent discrimination.

The HOPE score should not be considered a substitute for clinical judgment or assessment. Of note, one is of course free to use a different cut-off than the proposed threshold of 10% for different subgroups of the population (e.g. for children). Given the relatively low proportion of avalanche victims in the current validation study, it would be wise to use the HOPE score cautiously in this specific group of patients

 



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For complementary information please read the following references:

HOPE derivation study: Pasquier M, Hugli O, Paal P, Darocha T, Blancher M, Husby P, Silfvast T, Carron PN, Rousson V. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: The HOPE score. Resuscitation 2018.

HOPE external validation study: Pasquier M, Rousson V, Darocha T, Bouzat P, Kosiński S, Sawamoto K, Champigneulle B, Wiberg S, Wanscher M, Brodmann Maeder M, Hugli O. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE Score. Resuscitation 2019.

Editorial about the HOPE score: Gibbison B, Reeves BC. Forecasting HOPE: Risk prediction in rare events. Resuscitation 2019.